Sleeping with Other People : "Men and women can't be friends"

"Men and women can't be friends"

That line from Natasha Lyonne's character, are we supposed to think she actually means it? It seems like she's just referencing 'When Harry Met Sally', but Lainey takes it seriously and gets upset. If it's meant seriously, it just seems too stupid for anyone to say in real life - then it would make more sense with something like "People who are sexually attracted to each other can't be close friends".
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